[0:05]Integrins are protein complexes that are found within a cell's membrane and play important roles within the body. Integrins are obligate heterodimers with alpha and beta portions. When an extended open confirmation like this, the integrin is active. The extracellular head regions are responsible for binding extracellular matrix proteins.
[0:35]And the intracellular beta tails control the interactions within the cell. Resting integrins are held in the bent or closed confirmation. The alpha tail inhibits the beta tails interactions, rendering the receptor inactive. The integrin must be signaled to change confirmations.
